ABSTRACT
PURPOSE: To determine the effects of end-to-side nerve repair performed only with fibrin glue containing nerve growth in rats. METHODS: Seventy two Wistar rats were divided into six equal groups: group A was not submitted to nerve section; group B was submitted to nerve fibular section only. The others groups had the nerve fibular sectioned and then repaired in the lateral surface of an intact tibial nerve, with different procedures: group C: ETS with sutures; group D: ETS with sutures and NGF; group E: ETS with FG only; group F: ETS with FG containing NGF. The motor function was accompanied and the tibial muscle mass, the number and diameter of muscular fibers and regenerated axons were measured. RESULTS: All the analyzed variables did not show any differences among the four operated groups (p>0.05), which were statistically superior to group B (p<0.05), but inferior to group A (p>0.05). CONCLUSION: The end-to-side nerve repair presented the same recovery pattern, independent from the repair used, showing that the addition of nerve growth factor in fibrin glue was not enough for the results potentiating.
OBJETIVO: Determinar os efeitos do reparo nervoso término-lateral realizado apenas com cola de fibrina contendo fator de crescimento nervoso em ratos. MÉTODOS: Setenta e dois ratos Wistar foram distribuídos em seis grupos: A - não submetido à secção nervosa; B - secção do nervo fibular (sem reparo); Os outros grupos tiveram o nervo fibular seccionado e então reparado na superfície lateral do nervo tibial intacto, com diferentes procedimentos: C - RNTL com suturas; D - RNTL com suturas e FCN; E - RNTL apenas com CF; F - RNTL com CF contendo FCN. A função motora foi acompanhada e a massa do músculo tibial, o número e o diâmetro das fibras musculares e axônios regenerados foram medidos. RESULTADOS: Não houve diferença entre as variáveis avaliadas nos quatro grupos operados (p>0,05), os quais foram superiores ao grupo B (p<0,05), mas inferiores ao grupo A (p>0,05). CONCLUSÕES: O reparo nervoso término-lateral mostrou o mesmo padrão de recuperação, independente do tipo de reparo utilizado, evidenciando que a adição de fator de crescimento nervoso na cola de fibrina não foi suficiente para a potencialização dos resultados.
Subject(s)
Animals , Male , Rats , Fibrin Tissue Adhesive/therapeutic use , Nerve Growth Factor/therapeutic use , Nerve Regeneration/drug effects , Peroneal Nerve/drug effects , Tissue Adhesives/therapeutic use , Anastomosis, Surgical/methods , Nerve Endings/drug effects , Nerve Endings/physiology , Nerve Regeneration/physiology , Peroneal Nerve/injuries , Rats, WistarABSTRACT
Os autores relatam um caso de angiomixoma agressivo em paciente do sexo masculino, no cordão espermático. Essa entidade é descrita predominantemente em mulheres adultas, acometendo as regiões perineal, genital e pélvica. Macroscopicamente observou-se massa lobulada, infiltrativa, de limites imprecisos, que microscopicamente era representada por estroma mixóide com células pequenas, fusiformes e/ou estreladas, uniformes, sem figuras de mitose evidentes. Chamou atenção a presença de vasos sangüíneos proeminentes, de variados tamanhos, alguns deles com paredes espessadas. O perfil imuno-histoquímico mostrou positividade focal para desmina e actina de músculo liso (1A4) e negatividade para CD34 e CD68. Muitas neoplasias mixóides, tanto benignas quanto malignas, podem ser confundidas com o angiomixoma agressivo. O diagnóstico diferencial deve ser amplamente estudado, pois essa neoplasia tem caráter infiltrativo, alto índice de recorrência, embora não haja metástases relatadas até o presente momento.
Subject(s)
Humans , Male , Adult , Whipple Disease/diagnosis , Whipple Disease/pathology , Whipple Disease/drug therapyABSTRACT
Eosinophilic cystitis is a rare bladder disorder that was first reported in 1960 and can be diagnosed in children or adults. Its cause is unknown and usually presents with hematuria, supra pubic pain, sysuria and frequency. We have made an extensive literature review and we reported on 2 illustrative cases. The first case was a man presented with hematuria; a computed tomography, shown expansive process with a mass suggesting infiltration of the perivesical tissues. A biopsy was done and the pathological diagnosis was eosinophilic cystitis. The patient was treated with steroids. Later on, he had an episode of hematuria on the left ureteral orifice and a nephrouretectomy showed grade 2 urothelial carcinoma of the ureter. The second case is a child with neurogenic bladder due to myelomeningocele who had a cystostomy since the age of 5 months. Surgery was performed, including partial cystectomy with an ileal neobladder. The anatomopathological diagnosis was eosinophilic cystitis. The different classifications of eosinophilic cystitis were presented and discussed. The diagnosis of this entity can only be made by microscopic examination which shows mucosal edema or fibrosis, a polymorphous infiltrate rich in eosinophils and sometimes replacement of the bladder muscle by fibrotic tissue